Macro & Micro-Test helps rapid screening of Cholera

Cholera is an intestinal infectious disease caused by ingestion of food or water contaminated by Vibrio cholerae. It is characterized by acute onset, rapid and wide spread. It belongs to international quarantine infectious diseases and is Class A infectious disease stipulated by the Law of Infectious Disease Control in China. Especially. summer and autumn are the high incidence seasons of cholera.

There are currently more than 200 cholera serogroups, and two serotypes of Vibrio cholerae, O1 and O139, are capable of causing cholera outbreaks. Most outbreaks are caused by Vibrio cholerae O1. The O139 group, first identified in Bangladesh in 1992, was limited to spread in Southeast Asia. Non-O1 non-O139 Vibrio cholerae can cause mild diarrhea, but will not cause epidemics.

How cholera spreads

The main infectious sources of cholera are patients and carriers. During the onset period, patients can usually excrete bacteria continuously for 5 days, or for more than 2 weeks. And there are a large number of Vibrio cholerae in the vomiting and diarrhea, which can reach 107-109/ml.

Cholera is mainly transmitted by the fecal-oral route. Cholera is not airborne, nor can it be spread directly through the skin. But if the skin is contaminated with Vibrio cholerae, without washing hands regularly, food will be infected with Vibrio cholerae, the risk of illness or even the spread of the disease may occur if someone eats the infected food. In addition, Vibrio cholerae can be transmitted by infecting aquatic products such as fish and shrimp. People are generally susceptible to Vibrio cholerae, and there are no essential differences in age, gender, occupation, and race.

A certain degree of immunity can be acquired after the disease, but the possibility of reinfection also exists. Especially people living in areas with poor sanitation and medical conditions are susceptible to cholera disease.

Symptoms of cholera

The clinical features are sudden severe diarrhea, discharge of a large amount of rice swill-like excrement, followed by vomiting, water and electrolyte disturbance, and peripheral circulatory failure. Patients with severe shock may be complicated by acute renal failure.

In view of the reported cases of cholera in China, in order to avoid the rapid spread of cholera and endanger the world, it is urgent to carry out early, rapid and accurate detection, which is of great significance to prevent and control the spread.


Macro & Micro-Test has developed Vibrio cholerae O1 and Enterotoxin Gene Nucleic Acid Detection Kit(Fluorescence PCR). It provides assistance for the diagnosis, treatment, prevention and control of Vibrio cholerae infection. It also helps infected patients to diagnose quickly, and greatly improves the success rate of treatment.

Catalogue Number Product Name Specification
HWTS-OT025A Vibrio cholerae O1 and Enterotoxin Gene Nucleic Acid Detection Kit(Fluorescence PCR) 50 tests/kit
HWTS-OT025B/C/Z Freeze-dried Vibrio cholerae O1 and Enterotoxin Gene Nucleic Acid Detection Kit(Fluorescence PCR) 20 tests/kit, 50 tests/kit, 48 tests/kit


① Rapid: The detection result can be obtained within 40 minutes

② Internal Control: Fully monitor the experimental process to ensure the quality of experiments

③ High sensitivity: the LoD of the kit is 500 Copies/mL

④ High Specificity: No cross-reactivity with Salmonella, Shigella, Vibrio parahaemolyticus, Clostridium difficile, Escherichia coli and other common enteric pathogens.

Post time: Dec-23-2022