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Human CYP2C19 Gene Polymorphism Detection Kit (Fluorescence PCR)

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Human CYP2C19 Gene Polymorphism Detection Kit (Fluorescence PCR)

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Introduction

[Product Name] Human CYP2C19 Gene Polymorphism Detection Kit (Fluorescence PCR) [Packaging Size] 24 tests/kit
[Intended Use]
This kit is used for in vitro qualitative detection of the polymorphism of CYP2C19 genes CYP2C19*2 (rs4244285, c.681G>A), CYP2C19*3 (rs4986893, c.636G>A), CYP2C19*17 (rs12248560, c.806>T) in genomic DNA of human whole blood samples.

CYP2C19 is one of the important drug metabolizing enzymes in the CYP450 family. Many endogenous substrates and about 2% of clinical drugs are metabolized by CYP2C19, such as the metabolism of antiplatelet aggregation inhibitors (like clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, etc [1-2]. CYP2C19 gene polymorphisms also have differences in the metabolizing ability of related drugs. These point mutations of *2 (rs4244285) and *3 (rs4986893) cause the loss of the enzyme activity encoded by the CYP2C19 gene and the weakness of metabolic substrate ability, and increase the blood concentration, so as to cause adverse drug reactions related to blood concentration. *17 (rs12248560) could increase the enzyme activity encoded by CYP2C19 gene, the production of active metabolites, and enhance the platelet aggregation inhibition and increase the bleeding risk. For people with slow metabolism of drugs, taking normal doses for a long time will cause serious toxic and side effects: mainly liver damage, hematopoietic system damage, central nervous system damage, etc., that can lead to death in severe cases. According to the individual differences in the corresponding drug metabolism, it is generally divided into four phenotypes, namely ultra-fast metabolism (UM,*17/*17,*1/*17), fast metabolism (RM,*1/*1) , intermediate metabolism (IM, *1/*2, *1/*3), slow metabolism (PM, *2/*2, *2/*3, *3/*3) [3-5].

The test results of this kit only represent the test results of the human CYP2C19 gene, and provide a reference for clinicians’ personalized medicine. The test results of this kit are for clinical reference only, and should not be used as the sole basis for whether or not patients take medication. Clinicians should make comprehensive judgments on the test results of this kit in combination with the patient's condition, curative effect, and other laboratory test indicators.

[Storage Conditions and Shelf-life]

The kit should be stored stored at -18°C~-25°C away from light, and the shelf life is 12 months. The opening and the repeated freezing and thawing should be no more than four cycles.
See the packaging label for the production date and expiration date.

[Applicable Instruments]

Applied Biosystems 7500 Real-Time PCR Systems, Applied Biosystems 7500 Fast Real-Time PCR Systems, QuantStudio®5 Real-Time PCR Systems, SLAN-96P Real-Time PCR Systems(Shanghai Hongshi Medical Technology Co., Ltd. ), LightCycler®480 Real-Time PCR system, LineGene 9600 Plus Real-Time PCR Detection System(FQD-96A,Bioer technology), MA-6000 Real-Time Quantitative Thermal Cycler (Suzhou Molarray Co., Ltd.) , BioRad CFX96 Real-Time PCR System, BioRad CFX Opus 96 Real-Time PCR System.

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