Vancomycin-resistant Enterococcus and Drug-resistant Gene

Resistance to Drug is also known as drug resistance, refers to the resistance of bacteria to the action of antibacterial drugs. Once drug resistance occurs, the chemotherapy effect of drugs will be significantly reduced. Resistance to Drug is divided into intrinsic resistance and acquired resistance. Intrinsic resistance is determined by bacterial chromosomal genes, passed from generation to generation, and will not change. Acquired resistance is due to the fact that after contact with antibiotics, bacteria change their own metabolic pathways so that they are not killed by antibiotics.

The vancomycin resistance genes VanA and VanB are acquired drug resistance, among which VanA shows high levels of resistance to vancomycin and teicoplanin, VanB shows different levels of resistance to vancomycin, and is sensitive to teicoplanin. Vancomycin is often used clinically to treat Gram-positive bacterial infections, but due to the emergence of vancomycin-resistant enterococci (VRE), especially enterococcus faecalis and enterococcus faecium, accounting for more than 90%, it has brought new great challenges to clinical treatment. At present, there is no specific antibacterial drug for the treatment of VRE. What's more, VRE can also transmit drug resistance genes to other enterococci or other Gram-positive bacteria.